Pathogenesis of sperm granuloma

Federal government websites often end in. Before sharing sensitive information, make sure you're on a federal government site. The site is secure. Testis and epididymis. Academic Press, San Diego,
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Granulomatous orchitis and spermatic granuloma

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Epididymis - Sperm Granuloma

This area is rimmed by a zone of lymphocytes, plasma cells, epithelioid macrophages, and rare multinucleated giant cells that is further surrounded by thin band of fibrous connective tissue. Multifocally within the surrounding connective tissue, there are few lymphocytes, plasma cells, and occasional macrophages, some of which contain granular, golden-brown pigment hemosiderin. Within the epididymis there is diffuse aspermia. Within the testis, seminiferous tubules are degenerate with an undulant basement membrane, vacuolated Sertoli cells, and decreased amounts of mature sperm. Multifocally in the testis low numbers of similar inflammatory cells infiltrate and surround seminiferous tubules and there are rare multinucleated spermatids.
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One case of granulomatous orchitis and three cases of spermatic granuloma are described and the clinial and pathologic features of the two syndromes are discussed. Since no certain diagnosis is possible on clinical grounds alone, it rests on the evidence of pathology. Both granulomatous orchitis and spermatic granuloma are of practical importance to the specialists, the first being apt to mimic tumours, and the second to tuberculous epididymitis. Histological study, possibly of biopsy specimens, permits to differentiate either process from malignancy and from tuberculosis with certainty. It is to be emphasized that in many cases of chronic epididymitis with clinical suspicion of tuberculosis careful histological search reveals spermatic granuloma.
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